The European guidelines on risk assessment of chemicals have recently been amended (pesticides and biocides directives) in order to improve their ecological realism while limiting the use of tests on laboratory animals.
These new official texts all recommend the use of appropriate mathematical and statistical modeling tools for cognitive and predictive purposes.
Participants will learn to use MOSAIC, through a step-by-step guidance based on concrete practical examples. The objectives of this training are primarily to :
understand the issues of modeling as a tool for environmental risk assessment (ERA) related to the presence of xenobiotics;
know how to determine for a given species/substance combination critical effect concentrations on life history traits classically collected according to standard experimental protocols (e.g. for the constitution of marketing authorization dossiers for new molecules).
– Basic knowledge of statistics;
– Notions of standardized bioassays in biology or ecotoxicology, whether in a research or regulatory setting.
– Two-year technical degree (BAC+2)
23-24-25 of november 2022
Please note that you have until the 17 of november 2022 to register.
Virtual session on ZOOM
If you have a disability, do not hesitate to let us know at least 21 days before the training at firstname.lastname@example.org
DAY 1 – 23 of november 2022
13:00 – 13:15
13:15 – 14:45
Interest of modeling as a decision-help tool for environmental risk assessment (including the regulatory context) and presentation of the MOSAIC platform.
14:45 – 15:15 Break
15:15 – 16:45
Using MOSAIC (self-paced) to determine standard toxicity values:
- From survival or mobility data
- From reproductive data
- From growth data
16:45 – 17:00 Q/A
DAY 2 – 24 of november 2022
12:00 – 13:45
Processing of practical examples (survival/reproduction/growth) continues
13:45 – 14:15 Break
14:15 – 15:45 Introduction to physiologically based kinetic modelling of bioaccumulation; what is doable in practice with MOSAIC?
15:45 – 16:00 Q/A
DAY 3 – 25 of november 2022
12:00 – 13:45
Using MOSAIC (self-paced) to determine bioaccumulation metrics (BCF/BSAF/BMF)
13:45 – 14:15 Break
14:15 – 15:15 Improvements in environmental risk assessment (including the regulatory context) to evaluate the bioaccumulation capacity of chemical substances
15:15 – 15:45 What’s next?
15:45 – 16:00 Discussion / evaluation of the training (anonymous online survey)
This training, available to all, aims to help company managers, engineers, quality engineers, researchers, students, ecologists, regulators, pharmacists, doctors, public health officials, citizens and other stakeholders to determine for a given species/substance pair the concentration above which the substance becomes toxic for the species, and consequently for the environment in which it lives and more generally for biodiversity.
There will also be opportunities to discover new online tools, aiming at a better quantitative approach of data analysis for ERA and which could eventually become part of the regulation.
A focus will be made on the species sensitivity analysis (SSD) method with the consideration of censored data and the quantification of uncertainty. TK models of bioaccumulation will also be discussed depending on the issues of interest to the participants.
At the end of the course, the instructor will suggest that you go back over the notions that were not clear, while making sure that most of the elements have been acquired. An evaluation of the acquired knowledge will be done collectively at the end of the session
More information :
- A survey will be sent to you by email at the end of the training session, in order to collect your impressions, comments and suggestions for improvement. Your answers will be strictly anonymous.
- Need more informations ? Please contact us : email@example.com